Manage your Blood glucose levels.
- Metformin is the first-line medication for type-2 diabetes to control blood sugar levels. It is also used in the treatment of polycystic ovary syndrome (PCOS).
- It is an “insulin sensitizer” which means that it works to make the cells in the body more receptive to insulin.
- When the cells are insulin sensitive, they are able to take more glucose from the blood to be used for energy.
Mechanism of action
- It lowers the blood sugar levels in type-2 diabetic patients by decreasing the amount of glucose released into the blood stream by the liver. Thus, it lowers the glucose production by liver.
- In type-2 diabetic patients, the glucose production by liver is 3-times more than a normal individual. Metformin reduces this by one-third.
(Kirpichnikov D et al.: Metformin: an update. Ann Intern Med. 2002; 137(1):25-33)
Metformin is generally well tolerated but it has some side effects such as:
- Vitamin B12 Deficiency.
- Long-term consumption or higher doses of metformin is associated with increased incidence of vitamin B12 deficiency (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019388/).
- Sleep disorders
- Metformin is a widely used anti-diabetic drug. Deterioration of sleep is an important unwanted side effect of metformin. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354927/)
- Lactic acidosis: Most serious side effect caused by metformin is lactic acidosis. Lactic acidosis happens when there is not enough oxygen in the body and too much lactic acid builds up in the blood. Dehydration and drinking large amounts of alcohol can bring on lactic acidosis. Metformin also worsens this state of lactic acidosis. Its symptoms include:
- Muscle pain
- Numbness in the arms & legs
- Trouble breathing
- Stomach pain
- Feeling very weak or dizzy
- Slow or uneven heart rate
- Nausea with vomiting
- U. S. Food and Drug Administration (FDA) gave safety announcement regarding metformin use by kidney patients. According to FDA, metformin increases the risk of developing a serious and potentially deadly condition called lactic acidosis in kidney patients consuming metformin.
(Kim M J et al.: Metformin-associated lactic acidosis:predisposing, factors and outcome. Endocrinol Metab 2015; 30:78-83)
Other general reported side effects
- Minor side effects including diarrhea, nausea and abdominal pain.
- Metformin does not signal the pancreas to release insulin due to which there is a little risk of low blood sugar (hypoglycemia) when taking this drug.
- Decreased appetite
- Heart burn
Are you on Metformin for a long time, then answering following five questions is very important
Do you feel muscle pain?
Do you feel numbness in your arms & legs?
Do you feel weakness or dizziness?
Do you have sleep disorder?
Is there change in your diet?
If YES Consult Your Doctor
FENUGREEK & DIABETES MANAGEMENT
- Research and traditional usage suggests that Fenugreek seeds (Trigonella foenum graecum) are among the best in terms of safety and efficacy. According to the clinical studies, seeds of Fenugreek are a rich source of fiber and have multiple benefits in patients with diabetes.
- Mechanism: Soluble fiber in fenugreek seeds helps to lower blood sugar by slowing down carbohydrate digestion & absorption and stimulate insulin.
- Blood sugar: Animal research suggests that fenugreek may also contain a substance that stimulates insulin production and improves blood sugar control. The bioactive components responsible for anti-diabetic activity of fenugreek are soluble fiber, alkaloids and amino acids. Soluble fibers delay the intestinal absorption of ingested sugar. 4-hydroxyisoleucine amino acid acts on pancreas to increase the release of insulin from islets of Langerhans. Thus, the risk of hypoglycemia, as in the case of metformin consumption, never originates while consuming fenugreek.
OTHER HEALTH BENEFITS
- Inflammation, gastrointestinal problems and muscle pain: Abebe W also suggested that fenugreek is indicated for inflammation, gastrointestinal problems and muscle pain. The bioactive components responsible for this activity of fenugreek include alkaloids, saponins, amino acids etc. These bioactive components contribute to the anti-inflammatory and anti-oxidant property of fenugreek.
- Cholesterol & heart conditions: Incorporation of fenugreek in the regular diet can promote healthy cholesterol levels and play a role in the treatment of heart conditions like atherosclerosis, also known as “hardening of the arteries.”
- Appetite: In case of metformin consumption, there is decrease in appetite but while consuming fenugreek, the appetite gets balanced because it increases the production of bile by the liver.
- Heartburn: Fenugreek can be an effective remedy for acid reflux orheartburn. Mucilage of fenugreek seeds coat the lining of the stomach and intestine and soothe irritated gastrointestinal tissues.
- Vitamins: It is also rich in many vital vitamins that are essential nutrients for optimum health, including thiamin, pyridoxine (vitamin B6), folic acid, riboflavin, niacin, vitamin A, and vitamin-C.
- Minerals: Fenugreek is an excellent sources of minerals likecopper, potassium, calcium, iron, selenium, zinc, manganese, and magnesium. Potassium is an important component of cell and body fluids that helps control heart rate and blood pressure by countering action on sodium. Iron is essential for red blood cell production and as a co-factor for cytochrome-oxidases enzymes.
FenfuroTM is a patented and clinically evaluated product for safe and effective management of blood sugar levels. Fenfuro is a first of its kind, safe nutraceutical derived from fenugreek seeds through a patented process. Through its unique scientific process, FENFURO concentrates the bioactive part of plants into a manageable dose, while removing the inert parts such as cellulose. Also, since a lot of healthy botanicals are not palatable, consuming their concentrate in capsule form in small dosage is a lot easier. FENFURO contains a rich variety of saponins and flavonoids. These substances are known to lower blood lipid level and help in insulin sensitization and glucose regulation. FENFURO is the first dual action insulin sensitizer.
A clinical evaluation of FENFURO was carried out on a total of 154 Type 2 diabetics for a period of 3 months, to determine its efficacy and safety. At the end of three months 83% of the patients reported decrease in fasting sugar levels and89% patients reported decrease in PP sugar levels. The patients also showed significant decrease in HbA1C levels as compared to respective baseline value. 48.8% of patients reported reduction in dosage of anti-diabetic therapy after regularly taking FENFURO.
- Wulffele MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, Donker AJ, Stehouwer CD.Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med. November 2003;254(5):455–63
- Gupta A, Gupta R and Lal B: Effect of Trigonella foenum graecum seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: A double blind placebo controlled study. J Assoc Physicians India 2001; 49:1057-1061
- Abebe W: Herbal medication: potential for adverse interactions with analgesic drugs. Journal of Clinical Pharmacy and Therapeutics 2002; 27:391–40.
- Mahajan R, Gupta K. Revisiting Metformin: Annual Vitamin B12 Supplementation may become Mandatory with Long-Term Metformin Use. J Young Pharm. 2010Oct;2(4):428-9. doi: 10.4103/0975-1483.71621. PubMed PMID: 21264109; PubMedCentral PMCID: PMC3019388.